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Finance & Business Development How To Launch A Biotech Start-Up W By Suzanne Elvidge, contributing editor hether in the early days of DNA cloning in the 1970s, or the boom of the 1980s and 1990s, biotechnology and biotech start-ups have represented the cutting edge of the biopharma and healthcare industry. For those fascinated by the idea of entering the hurly-burly start-up world, Index Ventures hosted "Playground" in October 2013, covering the entire process, from thinking up the idea for a new company to planning for the exit. FRAMING THE IDEA There are start-ups being created all the time, from university technology transfers to company spinoffs. And all of these are based on what seem — at the time, at least — to be brilliant ideas. "The idea needs to be far enough from conventional wisdom to be exciting, but not so far that people won't listen," says Stelios Papadopoulos, former vice chairman at Cowen & Company, an investment banking services firm. So what differentiates an idea that will make it through to a trade sale or IPO, and the one that falls at the first hurdle? And more importantly, how do you tell the difference? To have a realistic chance of making it through, a company needs to start with a robust technology. The technology needs to meet the following conditions: • It must be novel enough to patent; otherwise, there will be nothing to fund. • The company must have freedom to operate in the given arena, with rights to the IP and no overlapping patents. • There must be a good biological and clinical rationale behind the idea, and it must have at least the first 38 LifeScienceLeader.com signs of efficacy and safety. The target market must be underserved, or the potential product must have clear advantages over those already in the market, such as lower cost, a more durable response, easier to use, or more convenient dosing and administration. • The predicted development path must be consistent with the potentially available funding — meaning a fast R&D; timeline and relatively small clinical trials. Once the idea has been formulated, the entrepreneur next has to validate the market. As Ben Miles, who created Flow Microfluidics (a company that fabricates microfluidic chips to a customer's design) while still a doctoral student, says, "There is no point working on a technology if there is no market." The route to market validation may not always be smooth. Miles initially tried to validate the potential market for his technology by creating a website where people could sign up, but only eight people registered, and only one of them converted into a customer. He found more success when he actually spoke to people in the relevant markets. • FINDING THE FUNDING Because biotechnology companies are capital-intensive and very heavily regulatFebruary 2014 ed, and the research often has a long timeline, funding is vital, as Kevin Johnson, partner, Index Ventures, explained, "Companies need cash, or there is no company." So, the next step is talking to investors. But before negotiations actually begin, it is important to take time to think about what the investors are looking for, and make sure that the idea behind the company fits what they need. The aim of a venture capitalist (VC) is to fund an idea that will provide a return — usually around $3 to $4 for every $1 invested — in order to cover the value of the fund and the VC's fee, and return a dividend to investors. In order to do that, ideas need to be both outstanding and strategic. Unpacking this concept further, an idea has to be outstanding not only today, but also in 5 or 10 years, when a lot may have changed in the science or the market. To be considered strategic, an idea has to be able to unlock a new market, or meet a critical, unmet need. Being able to fulfill both of these criteria will increase a company's chances of getting funding. However, while it may seem that the investor always holds the strongest card, it is important to remember that the fate of the investor really is in the hands of the entrepreneur. Investors are about more than just a supply of cash. They can also provide access to a network of contacts and routes