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BRI Biopharmaceutical Research Inc. Vancouver, BC Canada www.bripharm.com (604) 432-9237 Main Service Areas: Bioanalytical, Preclinical SERVICES & CAPABILITIES: GLP bioanalytical assays supporting tox and clinical PK, tumor cell lines and tumor xenograft models based on patient-derived orthotopic grafting, in vitro drug metabolism/ADME/bioavailability, in vivo drug metabolism and pharmacokinetics in tox species, drug substance and drug product stability program on clinical products THERAPEUTIC AREAS: Supported many oncology preclinical and clinical programs and other therapeutic areas (antiviral, anti-inflammatory, and cardiovascular), lymphomas KEY INDUSTRY PARTNERS: AP Sciences Inc. for cryopreserved hepatocytes TNERS: xxxxxxxxxxxxxxxxxxxx,xxxxxxxxxxxxxxxxxxxx,xxxxxxxxxxxxxxxxxxxxxxxxxxxxx,xxxxxxxxxxxxxxxxxxxxxxxxxxxx,xxxxxxxxxxxxxxxxxx "For nearly two decades, BRI has become recognized by its pharma and biotech clients for providing fit-for-purpose bioanalytical and DMPL studies supporting IND-enabling preclinical and clinical development. On behalf of our study teams and management at BRI, I am very pleased to have contributed to our clients' successful milestones over the years." — David Kwok, CEO Brixham Environmental Laboratory Brixham, Devon, UK www.Brixham-lab.com 44 (0) 1803 88 44 00 Main Service Areas: Bioanalytical SERVICES & CAPABILITIES: Support to environmental risk and impact assessments; assessment of acute and chronic effects to aquatic organisms, including full fish-life-cycles; assessment of potential to biodegrade/persist in the environment; analytical chemistry; all GLP-compliant and to world-wide regulations THERAPEUTIC AREAS: Regulatory ecotoxicology, environmental fate testing, analytical chemistry, physico-chemical analysis, mathematical modeling Key location: Brixham, Devon, UK Contact: Matthew Porter matthew.porter@astrazeneca.com Key location: Vancouver, British Columbia Contact: Clara Faan, VP sales cfaan@bripharm.com "Our knowledge of environmental regulations, both current and future, is supported by highly qualified staff who are among leading experts contributing to the process of developing and refining forthcoming guidelines for environmental testing. Our pricing is competitive and our recently refurbished, state-of-the-art testing and husbandry facili- ties offer one of the best equipped laboratories of its kind in Europe, if not the world." — Paul Duckett, laboratory director Charles River Laboratories International, Inc. Wilmington, MA www.criver.com (781) 222-6000 Main Service Areas: Bioanalytical, Preclinical SERVICES & CAPABILITIES: Preclinical services that include general and specialty toxicology, research models and services, pathology services, laboratory sciences, agrochemical and animal health product development, biopharmaceutical testing and manufacturing THERAPEUTIC AREAS: Whatever your area of research, Charles River provides the products and support services necessary for the discovery and development of the novel treatments you are searching for to help patients live healthier lives. A few of the many therapeutic areas include cardiovascular, endocrine/metabolic, oncology, skeletal disease, central nervous system, inflammation ophthalmology, vaccines, biosimilars, and cellular therapies. KEY INDUSTRY PARTNERS: Charles River partners with pharmaceutical and biotechnology companies, government agencies, and leading academic institutions around the globe to accelerate their research and drug development efforts. "At Charles River, we invest continuously in our people and portfolio to ensure that we have the expertise as well as the products and services to support our clients' drug devel- opment programs. Our passion for scientific excellence is a strong foundation for client relationships, which play a pivotal role in developing the flexible research platforms that are integral to delivering innovative health solutions. We are pleased that the marketplace recognizes, with this award, our commitment to clients." — James C. Foster, chairman, president, and chief executive officer The CRO Leadership Awards 2012 20 Key locations: Canada, France, Germany, Italy, Japan, United Kingdom, United States askcharlesriver@crl.com